2024

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LPS-induced lung tissue-resident trained innate immunity provides differential protection against pneumococci and SARS-CoV-2

Alisha Kang, Gluke Ye, Sam Afkhami, Fatemah Aleithan, Kanwaldeep Singh, Anna Dvorkin-Gheva, Tobias Berg, Matthew S Miller, Mangalakumari Jeyanathan, Zhou Xing. Cell Rep​. 2024 Oct 22;43(10):114849. doi: 10.1016/j.celrep.2024.114849. Epub 2024 Oct 9.

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Seasonal influenza vaccines: Variability of immune responses to B lineage viruses.

Matthew S Miller,  Emanuele Montomoli, Eyal Leshem, Michael Schotsaert, Thomas Weinke, Nevena Vicic, Deborah Rudin. Hum Vaccin Immunother​. 2024 Dec 31;20(1):2421096. doi: 10.1080/21645515.2024.2421096. Epub 2024 Nov 17.

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Contribution of immunoglobulin products in influencing seasonal influenza infection and severity in antibody immune deficiency patients receiving immunoglobulin replacement therapy.

Mark Ballow, Raúl Ortiz-de-Lejarazu, Isabella Quinti, Matthew S Miller, Klaus Warnatz. Front Immunol.​ 2024 Oct 22. doi: 10.3389/fimmu.2024.1452106. eCollection 2024.

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Hemagglutination-Inhibition Antibodies and Protection against Influenza Elicited by Inactivated and Live Attenuated Vaccines in Children.

Sergey Yegorov, Angela Brewer, Louis Cyr, Brian J Ward, Eleanor Pullenayegum, Matthew S Miller, and Mark Loeb.  J Infect Dis​. 2024 Nov 6. doi: 10.1093/infdis/jiae489.

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Examining the association between frailty and antibody neutralization of SARS-CoV-2: A multisite retrospective cohort study.

Zain Pasat, Jessica A. Breznik, Ahmad Rahim, Ali Zhang, Jann Ang, Tara Kajaks, Matthew S. Miller, Dawn M.E. Bowdish, Andrew P. Costa. Journal of the American Medical Directors Association. 2024 Apr; 25(4).

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Application of MALDI-TOF MS and machine learning for the detection of SARS-CoV-2 and non-SARS-CoV-2 respiratory infections.

Sergey Yegorov, Irina Kadyrova, Ilya Korshukov, Aidana Sultanbekova, Yevgeniya Kolesnikova, Valentina Barkhanskaya, Tatiana Bashirova, Yerzhan Zhunusov, Yevgeniya Li, Viktoriya Parakhina, Svetlana Kolesnichenko, Yelder Baiken, Bakhyt Matkarimov, Dmitriy Vazenmiller, Matthew S. Miller, Gonzalo H. Hortelano, Anar Turmukhambetova, Antonella E. Chesca, Dmitriy Babenko. Clinical Microbiology. 2024 Mar 18; 

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High-precision viral detection using electrochemical kinetic profiling of aptamer-antigen recognition in clinical samples and machine learning.

Payel Sen, Zijie Zhang, Sadman Sakib, Jimmy Gu, Wantong Li, Bal Ram Adhikari, Ariel Motsenyat, Jonathan L’Heureux-Hache, Jann C. Ang, Gurpreet Panesar, Bruno Salena, Debora Yamamura, Matthew S. Miller, Leyla Soleymani, Yingfu Li. Angewandte Chemie International Edition. 2024 Mar 8;

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Risk factors for recognized and unrecognized SARS-CoV-2 infection: a seroepidemiologic analysis of the Prospective Urban Rural Epidemiology (PURE) study.

Darryl P. Leong, Mark Loeb, Prem K. Mony, Sumathy Rangarajan, Maha Mushtaha, Matthew S. Miller, Mary Dias, Sergey Yegorov, Mamatha V., Ozge Telci Caklili, Ahmet Temizhan, Andrzej Szuba, Marc Evans M. Abat, Nafiza Mat-Nasir, Maria Luz Diaz, Hamda Khansaheb, Patricia Lopez-Jaramillo, MyLinh Duong, Koon K. Teo, Paul Poirier, Gustavo Oliveira, Alvaro Avezum, Salim Yusuf. Epidemiology. 2024 Jan 12;

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2023

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Immunomodulatory drugs have divergent effects on humoral and cellular immune responses to SARS-CoV-2 vaccination in people living with rheumatoid arthritis.

Jenna M. Benoit, Jessica A. Breznik, Jann C. Ang, Hina Bhakta, Angela Huynh, Braeden Cowbrough, Barbara Baker, Lauren Heessels, Sumiya Lodhi, Elizabeth Yan, Joycelyne Ewusie, Ishac Nazy, Jonathan Bramson, Matthew S. Miller, Sasha Bernatsky, Maggie J. Larche, Dawn M.E. Bowdish, the SUCCEED Investigator Group. Scientific Reports. 2023 Dec 21;

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The impact of Gam-COVID-Vac, an Adv5/Adv26 COVID-19 vaccine, on the biomarkers of endothelial function, coagulation and platelet activation.

Anar Turmukhambetova, Sergey Yegorov, Ilya Korshukov, Valentina Barkhanskaya, Svetlana Kolesnichenko, Dmitriy Klyuyev, Zhibek Zhumadilova, Aruzhan Pralieva, Laylim Absaghit, Ruslan Belyaev, Dmitriy Babenko, Gonzalo H. Hortelano, Matthew S. Miller, Dmitriy Vazenmiller, Irina Kadyrova. PLOS One. 2023 Oct 18; 

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Early humoral and cellular responses after bivalent SARS-CoV-2 mRNA-1273.214 vaccination in long-term care and retirement home residents in Ontario, Canada: An observation cohort study.

Jessica A. Breznik, Ahmad Rahim, Hina Bhakta, Rumi Clare, Ali Zhang, Jann Ang, Hannah D. Stacey, Li-Min Liu, Allison Kennedy, Lucas Bilaver, Megan Hagerman, Tara Kajaks, Jonathan L. Bramson, Ishac Nazy, Matthew S. Miller, Andrew P. Costa, Dawn M.E. Bowdish, the COVID in LTC Investigator Group. Journal of Medical Virology. 2023 Oct 11; 95(10)

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Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities.

Jessica A. Breznik, Ahmad Rahim, Ali Zhang, Jann Ang, Hannah D. Stacey, Hina Bhakta, Rumi Clare, Li-Min Liu, Allison Kennedy, Megan Hagerman, Tara Kajaks, Matthew S. Miller, Ishac Nazy, Jonathan L. Bramson, Andrew P. Costa, Dawn M.E. Bowdish. eClinicalMedicine. 2023 Sep 19; 63:

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Targeting the MR1-MAIT cell axis improves vaccine efficacy and afford protection against viral pathogens.

Rasheduzzaman Rashu, Marina Ninkov, Christine M. Wardell, Jenna M. Benoit, Nicole I. Wang, Courtney E. Meilleur, Michael R. D’Agostino, Ali Zhang, Emily Feng, Nasrin Saeedian, Gillian I. Bell, Fatemeh Vahedi, David A. Hess, Stephen D. Barr, Ryan M. Troyer, Chil-Yong Kang, Ali A. Ashkar, Matthew S. Miller, S.M. Mansour Haeryfar. PLOS Pathogens. 2023 June 29; ​

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SG-APSIC1054: Sputnik-V postvaccination immunologic rsponses in nasal mucosa: A prospective cohort study in Kazakhstan.

Irina Kadyrova, Svetlana Kolesnichenko, Ilya Korshukov, Yevgeniya Kolesnikova, Baurzhan Negmetzhanov, Yelder Baiken, Aidana Sultanbekova, Sergey Yegorov, Dmitriy Babenko, Bakhyt Matkarimov, Gonzalo Hortelano, Matthew S. Miller. Antimicrobial Stewardship & Healthcare Epidemiology. 2023 Mar 16; 

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Proceedings of the immune thrombocytopenia summit: new concepts in mechanisms, diagnosis, and management.

Syed Mahamad, Dimpy Modi, B.Tech, Hanny Al-Samkari, Adam Cuker, Jenny M. Despotovic, Joseph E. Italiano, Michele P. Lambert, Eun-Ju Lee, Matthew T. Rondina, Michelle Sholzberg, Caroline Kruse, Mark Larché, Ishac Nazy, Matthew S. Miller, Donald M. Arnold. Research and Practice in Thrombosis and Haemostasis. 2023 Feb 27: 100097.

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​Comparison of three dosing intervals for the primary vaccination of the SARS-CoV-2 mRNA Vaccine (BNT162b2) on magnitude, neutralization capacity and durability of the humoral immune response in health care workers: A prospective cohort study.

Darryl P. Leong, Ali Zhang, Jessica A. Breznik, Rumi Clare, Angela Huynh, Maha Mushtaha, Sumathy Rangarajan, Hannah Stacey, Paul Y. Kim, Mark Loeb, Judah A. Denburg, Dominik Mertz, Zain Chagla, Ishac Nazy, Matthew S. Miller, Dawn M. E. Bowdish, MyLinh Duong. Plos one. 2023 Feb 15;18(2): e0281673.

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Corrigendum: Differential biodistribution of adenoviral-vectored vaccine following intranasal and endotracheal deliveries leads to different immune outcomes. Vidthiya Jeyanathan, Sam Afkhami, Michael R. D’Agostino, Anna Zganiacz, Xueya Feng, Matthew S. Miller, Mangalakumari Jeyanathan, Michael R. Thompson, Zhou Xing. Frontiers in Immunology. 2023 Feb 6; 14: https://doi.org/10.3389/fimmu.2023.1151809.

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2022

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Three on Three: Universal and High-Affinity Molecular Recognition of the Symmetric Homotrimeric Spike Protein of SARS-CoV-2 with a Symmetric Homotrimeric Aptamer.

Jiuxing Li, Zijie Zhang, Jimmy Gu, Ryan Amini, Alexandria G. Mansfield, Jianrun Xia, Dawn White, Hannah D. Stacey, Jann C. Ang, Gurpreet Panesar, Alfredo Capretta, Carlos D. M. Filipe, Karen Mossman, Bruno J. Salena, Jonathan B. Gubbay, Cynthia Balion, Leyla Soleymani, Matthew S. Miller, Deborah Yamamura, John D. Brennan, and Yingfu Li. Journal of the American Chemical Society. 2022 Dec 15.

 

Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection.

Ali Zhang, Hannah D Stacey, Michael R D’Agostino, Yona Tugg, Art Marzok, Matthew S Miller. Nature Reviews Immunology. 1 - 16. 2022 December 19.​

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Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination.

Jessica A Breznik, Angela Huynh, Ali Zhang, Lucas Bilaver, Hina Bhakta, Hannah D Stacey, Jann C Ang, Jonathan L Bramson, Ishac Nazy, Matthew S Miller, Judah Denburg, Andrew P Costa, Dawn ME Bowdish, COVID-in-LTC Investigator Group. The Journal of Immunology. 209 (10): 1892-1905. 2022 November 15. 

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Sustained Delivery of a Monoclonal Antibody against SARS-CoV-2 by Microencapsulated Cells: A Proof-of-Concept Study.

Assem Ashimova, Askhat Myngbay, Sergey Yegorov, Baurzhan Negmetzhanov, Irina Kadyrova, Angelina Yershova, Ulpan Kart, Matthew S Miller, Gonzalo Hortelano. Pharmaceutics. 14 (10): 2042. 2022 September 24. 

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Protocol for isolation and characterization of lung tissue resident memory T cells and airway trained innate immunity after intranasal vaccination in mice

Michael R D’Agostino, Sam Afkhami, Alisha Kang, Art Marzok, Matthew S Miller, Zhou Xing. STAR Protocols. 3 (3): 101652. 2022 September 16. 

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Hemagglutinin stalk-binding antibodies enhance effectiveness of neuraminidase inhibitors against influenza via Fc-dependent effector functions

Ali Zhang, Hanu Chaudhari, Yonathan Agung, Michael R D’Agostino, Jann C Ang, Yona Tugg, Matthew S Miller. Cell Reports Medicine. 3 (8): 100718. 2022 August 16. 

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Sputnik-V reactogenicity and immunogenicity in the blood and mucosa: a prospective cohort study

Sergey Yegorov, Irina Kadyrova, Baurzhan Negmetzhanov, Yevgeniya Kolesnikova, Svetlana Kolesnichenko, Ilya Korshukov, Yeldar Baiken, Bakhyt Matkarimov, Matthew S Miller, Gonzalo H Hortelano, Dmitriy Babenko. Scientific Reports. 12 (1): 1-12 . 2022 August 1. 

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High SARS-CoV-2 seroprevalence in Karaganda, Kazakhstan before the launch of COVID-19 vaccination

Irina Kadyrova, Sergey Yegorov, Baurzhan Negmetzhanov, Yevgeniya Kolesnikova, Svetlana Kolesnichenko, Ilya Korshukov, Lyudmila Akhmaltdinova, Dmitriy Vazenmiller, Yelena Stupina, Naylya Kabildina, Assem Ashimova, Aigul Raimbekova, Anar Turmukhambetova, Matthew S Miller, Gonzalo Hortelano, Dmitriy Babenko. Plos one. 17 (7): e0272008 . 2022 July 27. 

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Differential biodistribution of adenoviral-vectored vaccine following intranasal and endotracheal deliveries leads to different immune outcomes

Vidthiya Jeyananthan, Sam Afkhami, Michael R D'Agostino, Anna Zganiacz, Xueya Feng, Matthew Miller, Mangalakumari Jeyanathan, Michael R Thompson, Zhou Xing. Frontiers in Immunology. 2808. 2022 June 10. 

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Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycle

Daniel Favre, Jackson F Harmon, Ali Zhang, Matthew S Miller, Igor A Kaltashov. Journal of Inorganic Biochemistry. 111899. 2022 June 9. 

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Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection

Amanda J Lee, Emily Feng, Marianne V Chew, Elizabeth Balint, Sophie M Poznanski, Elizabeth Giles, Ali Zhang, Art Marzok, Spencer D Revill, Fatemeh Vahedi, Anisha Dubey, Ehab Ayaub, Rodrigo Jimenez-Saiz, Joshua JC McGrath, Tyrah M Ritchie, Manel Jordana, Danny D Jonigk, Maximilian Ackermann, Kjetil Ask, Matthew Miller, Carl D Richards, Ali A Ashkar PLoS Pathogens. 2022 April 5. 18 (5): e1010471. 

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Front Cover: A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern 

Zijie Zhang, Jiuxing Li, Jimmy Gu, Ryan Amini, Hannah D Stacey, Jann C Ang, Dawn White, Carlos DM Filipe, Karen Mossman, Matthew S Miller, Bruno J Salena, Deborah Yamamura, Payel Sen, Leyla Soleymani, John D Brennan, Yingfu Li. Chemistry. 2022 March 3. 28 (15): 896-915 e 19. ​

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Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2.

Sam Afkhami, Michael R D'Agostino, Ali Zhang, Hannah D Stacey, Art Marzok, Alisha Kang, Ramandeep Singh, Jegarubee Bavananthasivam, Gluke Ye, Xiangqian Luo, Fuan Wang, Jann C Ang, Anna Zganiacz, Uma Sankar, Natallia Kazhdan, Joshua F E Koenig, Allyssa Phelps, Steven F Gameiro, Shangguo Tang, Manel Jordana, Yonghong Wan, Karen L Mossman, Mangalakumari Jeyanathan, Amy Gillgrass, Maria Fe C Medina, Fiona Smaill, Brian D Lichty, Matthew S Miller, Zhou Xing. Cell. 20222 March 3. 185 (5): 896-915 e 19.

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Adenovirus 5 Vectors Expressing SARS-CoV-2 Proteins.

Scott Bachus, Nikolas Akkerman, Lauren Fulham, Drayson Graves, Caelan Stephanson, Harram Memon, Matthew S Miller, Peter Pelka. mSphere. 2022 April 27. doi: 10.1128/msphere.00998-21. Epub 2022 Feb 28 

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Inactivated and live-attenuated seasonal influenza vaccines boost broadly neutralizing antibodies in children.

Sergey Yegorov, Daniel B Celeste, Kimberly Braz Gomes, Jann C Ang, Colin Vandenhof, Joanne Wang, Ksenia Rybkina, Vanessa Tsui, Hannah D Stacey, Mark Loeb, Matthew S Miller. The European respiratory journal. 2022.​

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Cigarette smoke augments CSF3 expression in neutrophils to compromise alveolar-capillary barrier function during influenza infection. 

Joshua J C McGrath, Gilles Vanderstocken, Anna Dvorkin-Gheva, Steven P Cass, Sam Afkhami, Matthew F Fantauzzi, Danya Thayaparan, Amir Reihani, Peiyao Wang, Ashley Beaulieu, Pamela Shen, Mathieu Morissette, Rodrigo Jiménez-Saiz, Spencer D Revill, Arata Tabuchi, Diana Zabini, Warren L Lee, Carl D Richards, Matthew S Miller, Kjetil Ask, Wolfgang M Kuebler, Jeremy A Simpson, Martin R Stämpfli. The European respiratory journal. 2022.

Antibody Responses to Third-Dose mRNA Vaccines in Nursing Home and Assisted Living Residents.

Ali Zhang, Jessica A Breznik, Rumi Clare, Ishac Nazy, Matthew S Miller, Dawn M E Bowdish, Andrew P Costa. J Am Med Dir Assoc​. 2022 Jan 15;S1525-8610(21)01109-9. 

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Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice.

Brittany M.Duggan, Akhilesh K.Tamrakar, Nicole G.Barra, Fernando F.Anhê, GabriellaPaniccia, Jessica G.Wallace, Hannah D.Stacey, Michael G.Surette, Matthew S. Miller, Deborah M.Sloboda, Jonathan D.Schertzer. Molecular Metabolism, 2022-01-01, Volume 55, Article 101404​​

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2021​

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Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents.

Jessica A Breznik, Ali Zhang, Angela Huynh, Matthew S Miller, Ishac Nazy, Dawn M E Bowdish, Andrew P Costa. J Am Med Dir Assoc​. 2021 Dec;22(12):2512-2514. doi: 10.1016/j.jamda.2021.10.001.

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Potentiation of long-acting β 2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP.

Yechan Kim, Vincent Hou, Ryan D Huff, Jennifer A Aguiar, Spencer Revill, Nicholas Tiessen, Quynh Cao, Matthew S Miller, Mark D Inman, Kjetil Ask, Andrew C Doxey, Jeremy A Hirota. Respir Res. 2021 Oct 19;22(1):266. doi: 10.1186/s12931-021-01862-1.

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High-Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild-Type and B.1.1.7 SARS-CoV-2 in Unprocessed Saliva.

Zijie Zhang, Richa Pandey, Jiuxing Li, Jimmy Gu, Dawn White, Hannah D Stacey, Jann C Ang, Catherine-Jean Steinberg, Alfredo Capretta , Carlos D M Filipe, Karen Mossman, Cynthia Balion, Matthew S Miller, Bruno J Salena, Deborah Yamamura, Leyla Soleymani, John D Brennan, Yingfu Li. Angew Chem Int Ed Engl. 2021 Nov 2;60(45):24266-24274. doi: 10.1002/anie.202110819.

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Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library.

Jiuxing Li, Zijie Zhang, Jimmy Gu, Hannah D Stacey, Jann C Ang, Alfredo Capretta, Carlos D M Filipe, Karen L Mossman, Cynthia Balion, Bruno J Salena, Deborah Yamamura, Leyla Soleymani, Matthew S Miller, John D Brennan, Yingfu Li. Nucleic Acids Res. 2021 Jul 21. doi: 10.1093/nar/gkab574. PMID: 34232998

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IgA potentiates NETosis in response to viral infection.

Hannah D Stacey, Diana Golubeva, Alyssa Posca, Jann C Ang, Kyle E Novakowski, Muhammad Atif Zahoor, Charu Kaushic, Ewa Cairns, Dawn M E Bowdish, Caitlin E Mullarkey, Matthew S Miller. Proc Natl Acad Sci U S A. 2021 Jul 6. doi: 10.1073/pnas.2101497118. PMID: 34183391

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Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract.

Joshua J C McGrath, Danya Thayaparan, Steven P Cass, Jonathan P Mapletoft, Peter Y F Zeng, Joshua F E Koenig, Matthew F Fantauzzi, Puja Bagri, Bruce Ly, Rachel Heo, L Patrick Schenck, Pamela Shen, Matthew S Miller, Martin R Stämpfli. Mucosal Immunol. 2021 Jun 9. 

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Neutrophils and Influenza: A Thin Line between Helpful and Harmful.

Sneha T George, Jonathan Lai, Julia Ma, Hannah D Stacey, Matthew S Miller, Caitlin E Mullarkey. Vaccines (BaseI). 2021 Jun 4. doi: 10.3390/vaccines9060597. PMID: 34199803

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A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge.

Zachary R Sia, Xuedan He, Ali Zhang, Jann C Ang, Shuai Shao, Amal Seffouh, Wei-Chiao Huang, Michael R D'Agostino, Amir Teimouri Dereshgi, Sambhara Suryaprakash, Joaquin Ortega, Hanne Andersen, Matthew S Miller, Bruce A Davidson, Jonathan F Lovell. Proc Natl Acad Sci U S A. 2021 Jun 1. doi: 10.1073/pnas.2025759118. PMID: 34050027

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Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses.

Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, Rajesh Abraham Jacob, Daniel Richard, Hassaan Maan, Jennifer A Aguiar, Wael L Demian, Kaushal Baid, Michael R D'Agostino, Jann Catherine Ang, Tetyana Murdza, Benjamin J-M Tremblay, Sam Afkhami, Mehran Karimzadeh, Aaron T Irving, Lily Yip, Mario Ostrowski, Jeremy A Hirota, Robert Kozak, Terence D Capellini, Matthew S Miller, Bo Wang, Samira Mubareka, Allison J McGeer, Andrew G McArthur, Andrew C Doxey, Karen Mossman. iScience. 2021 May 21. doi: 10.1016/j.isci.2021.102477. Epub 2021 Apr 26. PMID: 33937724

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Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets.

Eden Kapcan, Benjamin Lake, Zi Yang, Ali Zhang, Matthew S Miller, Anthony F Rullo. Biochemistry. 2021 May 18. doi: 10.1021/acs.biochem.1c00127. Epub 2021 Apr 30. PMID: 33930269

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Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects.

Angela Huynh, Donald M Arnold, James W Smith, Jane C Moore, Ali Zhang, Zain Chagla, Bart J Harvey, Hannah D Stacey, Jann C Ang, Rumi Clare, Nikola Ivetic, Vasudhevan T Chetty, Dawn M E Bowdish, Matthew S Miller, John G Kelton, Ishac Nazy. Viruses. 2021 Apr 16. doi: 10.3390/v13040697. PMID: 33923828

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2020​

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Probe Design for Simultaneous, Targeted Capture of Diverse Metagenomic Targets.

Zachery W Dickson, Dirk Hackenberger, Melanie Kuch, Art Marzok, Arinjay Banerjee, Karen Mossman, Matthew S Miller, Geoffrey B Golding, Hendrik Poinar. Cell Rep Methods. 2020 Dec 23. doi: 10.2139/ssrn.3754546

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Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike. 

Jérémie Prévost , Romain Gasser , Guillaume Beaudoin-Bussières , Jonathan Richard , Ralf Duerr , Annemarie Laumaea , Sai Priya Anand , Guillaume Goyette , Mehdi Benlarbi , Shilei Ding , Halima Medjahed , Antoine Lewin , Josée Perreault , Tony Tremblay , Gabrielle Gendron-Lepage , Nicolas Gauthier , Marc Carrier , Diane Marcoux , Alain Piché , Myriam Lavoie , Alexandre Benoit , Vilayvong Loungnarath , Gino Brochu , Elie Haddad, Hannah D Stacey , Matthew S Miller , Marc Desforges , Pierre J Talbot , Graham T Gould Maule , Marceline Côté , Christian Therrien , Bouchra Serhir , Renée Bazin , Michel Roger , Andrés Finzi.  Cell Rep Med. 2020 Oct 20. 1(7): 100126. DOI: 10.1016/j.xcrm.2020.100126

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Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus.

Arinjay Banerjee, Andrew C Doxey, Benjamin J-M Tremblay, Michael J Mansfield, Sonu Subudhi, Jeremy A Hirota, Matthew S Miller, Andrew G McArthur, Samira Mubareka, Karen Mossman. J Gen Virol. 2020 Sep 9. PMID: 32902372. DOI: 10.1099/jgv.0.001491

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Immunological considerations for COVID-19 vaccine strategies. 

Mangalakumari Jeyanathan, Sam Afkhami, Fiona Smaill, Matthew S Miller, Brian D Lichty, Zhou Xing. Nat. Rev. Immunol. 2020 Sep 4. 1-18. doi: 10.1038/s41577-020-00434-6.

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Engineered Nanoparticle Applications for Recombinant Influenza Vaccines.  

Zachary R Sia, Matthew S Miller, Jonathan F Lovell. Mol Pharm. 2020 Aug 17. doi: 10.1021/acs.molpharmaceut.0c00383. Online ahead of print.PMID: 32787280

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Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.  

Jennifer A Aguiar, Benjamin J-M Tremblay, Michael J Mansfield, Owen Woody, Briallen Lobb, Arinjay Banerjee, Abiram Chandiramohan, Nicholas Tiessen, Quynh Cao, Anna Dvorkin-Gheva, Spencer Revill , Matthew S Miller, Christopher Carlsten, Louise Organ, Chitra Joseph, Alison John, Paul Hanson , Richard Austin, Bruce M McManus, Gisli Jenkins, Karen Mossman, Kjetil Ask, Andrew C Doxey, Jeremy A Hirota.  Eur Respir J. 2020 Jul 16:2001123. doi: 10.1183/13993003.01123-2020. Online ahead of print.PMID: 3267520  

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Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2.  

Arinjay Banerjee, Jalees A Nasir, Patrick Budylowski, Lily Yip, Patryk Aftanas, Natasha Christie, Ayoob Ghalami, Kaushal Baid, Amogelang R Raphenya, Jeremy A Hirota, Matthew S Miller, Allison J McGeer, Mario Ostrowski, Robert A Kozak, Andrew G McArthur, Karen Mossman, Samira Mubareka.  Emerg Infect Dis. 2020 Jun 19;26(9). doi: 10.3201/eid2609.201495. Online ahead of print.PMID: 32558639 

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Bat Influenza Viruses: Making a Double Agent of MHC Class II. 

Arinjay Banerjee, Karen L. Mossman, Matthew S. Miller.  Trends Microbiol. 2020 Sep;28(9):703-706. doi: 10.1016/j.tim.2020.04.006. Epub 2020 Apr 20.PMID: 3240914

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Age-specific incidence of influenza A responds to change in virus subtype dominance.

Alain Gagnon, Erinque Acosta, Matthew S. Miller. Demography. 2019 Oct 28. doi: 10.1007/s13524-019-00824-z. Online ahead of print.PMID: 31659681

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Repeated Seasonal Influenza Vaccination-How Much is Too Much of a Good Thing?

Hannah D. Stacey and Matthew S. Miller. J Infect Dis. 2020 Jun 29;222(2):173-175. doi: 10.1093/infdis/jiz434.

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2019​

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Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016.

Acosta, E., Hallman S., Dillon LY, Ouellette N, Bourbeau R, Herring DA, Inwood Kb, Earn DJ, Madrenas J, Miller MS, Gagnon A. Demography. 2019 Oct;56(5):1723-1746.

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Comparative Immunogenicity of the 2014–2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children.

Jann Catherine Ang, Biao Wang, Joanne J.F. Wang, Peter Yu Fan Zeng, Florian Krammer, Brian J. Ward, Margaret L. Russell, Mark Loeb, and Matthew S. Miller.  Vaccines. 2019 August 7. Accepted.

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Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films.

Vincent Leung, Jonathan Mapletoft, Ali Zhang, Amanda Lee, Fatemeh Vahedi, Marianne Chew, Alexandra Szewczyk, Jann Ang, Braeden Cowbrough, Matthew Miller, Ali Ashkar, and Carlos Filipe. Scientific Reports. 2019 May 7. Accepted.

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Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders.

Steve P. Toniolo, Sam Afkhami, Ahmad Mahmood, Cecile Fradin, Brian D. Lichty, Matthew S. Miller, Zhou Xing, Emily D. Cranston, and Michael R. Thompson. International Journal of Pharmaceutics. 2019 February 19;108:173-178. doi: 10.1016/j.ijpharm.2019.02.035. 

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Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses.

Ali Zhang, Hannah D. Stacey, Caitlyn E Mullarkey, Matthew S. Miller. J Immunol. 2019 Jan 15;202(2):335-340. doi: 10.4049/jimmunol.1801149. 

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2018​

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Reviewing the evidence for viruses as environmental risk factors for ALS: A new perspective.

Daniel B. Celeste and Matthew S. Miller . Cytokine. 2018 Apr 20;108:173-178. doi: 10.1016/j.cyto.2018.04.010. 

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“Gnothi Seauton”: Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy

Hannah D. Stacey, Neda Barjesteh, Jonathan P. Mapletoft  and Matthew S. Miller . Vaccines 2018, 6(2), 23; doi:10.3390/vaccines6020023

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Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic

Alain Gagnon, Enrique Acosta, Stacey Hallman, Robert Bourbeau, Lisa Y. Dillon, Nadine Ouellette, David J.D. Earn, D. Ann Herring, Kris Inwood, Joaquin Madrenas, Matthew S. Miller. mBio vol 9(1). e2091-17

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2017​

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Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. 

Wenqian He, Chi-Jene Chen, Caitlin E Mullarkey, Jennifer R Hamilton, Christine Wong, Paul E Leon, Melissa B Uccellini, Veronika Chromikova, Carole Henry, Kevin W Hoffman, Jean K Lim, Patrick C Wilson, Matthew S Miller, Florian Krammer, Peter Palese and Gene S Tan. 2017. Nature Communications 8(1):846.

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Regulation of kynurenine biosynthesis during influenza virus infection.

Lana Gaelings, Sandra Söderholm, Andrii Bugai, Yu Fu, Jatin Nandania, Bert Schepens, Martina B. Lorey, Janne Tynell, Liesbeth Vande Ginste, Ronan Le Goffic, Matthew S Miller, Marika Kuisma, Varpu Marjomäki, Jef De Brabander, Sampsa Matikainen, Tuula A. Nyman, Dennis H Bamford, Xavier Saelens, Ilkka Julkunen, Henrik Paavilainen, Veijo Hukkanen, Vidya Velagapudi, Dennis E Kainov. 2017. FEBS J. 286:222-236. 

 

2016​

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Broadly neutralizing hemagglutinin stalk-specific antibodies induce potent phagocytosis of immune complexes by neutrophils in an Fc-dependent manner.

Caitlin E Mullarkey, Mark Bailey, Diana Golubeva, Gene Tan, Raffael Nachbagauer, Wenqian He, Kyle Novakowski, Dawn Bowdish, Matthew S Miller, and Peter Palese. 2016. mBio,7(5), pii: e01624-16.​

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Abnormal Regulation of the Antiviral Response in Neurological/Neurodegenerative Diseases.

Mannie Man Wai Lam, Jonathan P Mapletoft and Matthew S Miller. 2016. Cytokine, 88:251-258.​

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Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza A virus

Wenqian He, Gene S Tan, Caitlin E Mullarkey, Amanda J Lee, Mannie Man Wai Lam, Florian Krammer, Carole Henry, Patrick C Wilson, Ali A Ashkar, Peter Palese and Matthew S Miller. 2016. Proc Natl Acad Sci USA, 113(42):11931-11936. ​

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Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact 

Paul E Leon, Wenqian He, Caitlin E Mullarkey, Mark J Bailey, Matthew S Miller, Florian Krammer, Peter Palese and Gene S Tan. 2016. Proc Natl Acad Sci USA, 113(40).​

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Autoimmune variant PTPN22 C1858T is associated with impaired responses to influenza virus vaccination

Juliet N. Crabtree, Wenqian He, Weihua Guan, Mark Flage,  Matthew S Miller,  Erik J. Peterson. 2016. J Infect Dis. 214(2): 248-57​

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CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

Changying Jiang, Zhicheng Zhou, Yanping Quan, Shilei Zhang, Tingting Wang, Xueqiang Zhao, Clayton Morrison, Mark T. Heise, Wenqian He, Matthew S. Miller, Xin Lin. 2016.Cell Reports. 14(10): 2389-401.

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2015

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Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets.

Raffael Nachbagauer, Matthew S Miller, Rong Hai, Alex Ryder, John Rose, Peter Palese, Adolfo García-Sastre, Florian Krammer, and Randy Albrecht. 2015. Journal of Virology. 90:3268-73

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Measuring the neutralization potency of influenza A virus hemagglutinin stalk/stem-binding antibodies in polyclonal preparations by microneutralization assay.

Wenqian He, Caitlin E Mullarkey and Matthew S. Miller. 2015. Methods  pii: S1046-2023(15)00191-7.

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SETX suppresses the antiviral transcriptional response and controls viral biogenesis.

Matthew S. Miller, Alexander Rialdi, Jessica Sook Yuin Ho, Micah Tilove, Luis Martinez-Gil, Natasha P. Moshkina,  Zuleyma Peralta, Justine Noel, Camilla Melegari,  Ana Maestre, Panagiotis Mitsopoulos, Joaquín Madrenas, Sven Heinz, Chris Benner, John A. T. Young, Alicia R. Feagins, Christopher Basler,  Ana Fernandez-Sesma, Olivier J. Becherel, Martin F. Lavin, Harm van Bakel, and Ivan Marazzi. 2015.  Nat Immunol. 16:485-494.

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Is Antigenic Sin always "original?": Re-examining the evidence regarding circulation of a human H1 influenza virus immediately prior to the 1918 Spanish Flu.

Alain Gagnon, Enrique Acosta and Matthew S. Miller. 2015.  PLoS Pathog. 11:e1004615

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Broadly-Neutralizing Anti-Influenza Virus Antibodies: Enhancement of Neutralizing Potency in Polyclonal Mixtures and IgA Backbones.

Wenqian He, Caitlin Mullarkey, J Duty, Thomas Moran, Peter Palese and Matthew S. Miller. 2015. J Virol 89:3610-3618

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2014​

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Induction of broadly cross reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.

Ali H. Ellebedy, Florian Krammer, Gui-Mei Li, Matthew S. Miller, Christopher Chiu, Jens Wrammert, Cathy Y. Cheng, Carl W. Davis, Megan McCausland, Rivka Elbein, Srilatha Edupuganti, Paul Spearman, Sarah F. Andrews, Patrick C. Wilson, Adolfo Garcia-Sastre, Mark J. Mulligan,  Aneesh K. Mehta, Peter Palese and Rafi Ahmed. 2014. Proc Natl Acad Sci U S A. 111:13133-13138

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Peering into the crystal ball: Predicting influenza pandemics and vaccine efficacy.

Matthew S. Miller and Peter Palese. 2014. Cell 157:294-299

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Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.

Florian Krammer, Rong Hai, Mark Yondola, Gene Tan, Victor Levya-Grado, Alex Ryder, Matthew S. Miller, John Rose, Peter Palese, Adolfo Garcia-Sastre and Randy Albrecht. 2014. J Virol. 88:3432-3442

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2013​

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Neutralizing antibodies against previously-encountered influenza virus strains increase over time: A longitudinal analysis.

Matthew S. Miller, Thomas J. Gardner, Florian Krammer, Lauren C. Aguado, Domenico Tortorella, Christopher F. Basler and Peter Palese. 2013. Sci Transl Med 5:198ra107

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Age-specific mortality during the 1918 influenza pandemic: Unravelling the mystery of high young adult mortality.

Alain Gagnon, Matthew S. Miller, Stacey Hallman, Robert Bourbeau, D. Ann Herring, David J.D. Earn and Joaquin Madrenas. 2013. PLoS One 8:e69586.

 

Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus.

Judith Alamares-Sapuay, Luis Martinez-Gil, Silke Stertz, Matthew S. Miller, Megan Shaw and Peter Palese. 2013. J Virol. 87:6020-6026.

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1976 and 2009 H1N1 influenza virus vaccines boost anti-hemagglutinin stalk antibodies in humans.

Matthew S. Miller, Tshidi Tsibane, Florian Krammer, Rong Hai, Saad Rahmat, Christopher F. Basler and Peter Palese. 2013. J Infect. Dis. 207:98-105.

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2012​

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Characterization of the 55 residue protein encoded by the 9S E1A mRNA of species C adenovirus.

Matthew S. Miller, Peter Pelka, Gregory J. Fonseca, Michael J. Cohen, Jenna N. Kelly, Stephen D. Barr, Roger J. A. Grand, Andrew S. Turnell, Peter Whyte, Joe S. Mymryk. 2012. J Virol. 86:4222-4233

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2011​

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An Unhealthy Relationship: Viral Manipulation of the Nuclear Receptor Superfamily.

Matthew S. Miller and Joe S. Mymryk. 2011. Future Microbiol. 6:999-1019.

 

Adenovirus E1A directly targets the DP-1/E2F complex. 

Peter Pelka, Matthew S. Miller, Matthew Checchini, Ahmed Fayed Yousef, Dawn M. Bowdish, Fred Dick, Peter Whyte and Joe S. Mymryk. 2011. J Virol. 85:8841-8851.

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2010​

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RASCAL is a new human cytomegalovirus-encoded protein localizing to the nuclear lamina and in cytoplasmic vesicles at late times post-infection.

Matthew S. Miller, Leesa Pennell, Wendy E. Furlong, Marc Geadah and Laura Hertel. 2010. J Virol. 84:6483-6496.

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2009

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Onset of human cytomegalovirus replication in fibroblasts requires the presence of an intact vimentin cytoskeleton.

Matthew S. Miller and Laura Hertel. 2009. J Virol. 83:7015-1728.

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Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis.

Lana Mandic, Matthew S. Miller, Corinne Coulter, Brian Munshaw and Laura Hertel. 2009. J Gen. Virol. 90:1172-1182