2019

Comparative Immunogenicity of the 2014-2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children.

Acosta, E., Hallman S.Dillon LYOuellette NBourbeau RHerring DAInwood KbEarn DJMadrenas JMiller MSGagnon A. Demography. 2019 Oct;56(5):1723-1746.

Repeated Seasonal Influenza Vaccination-How Much is Too Much of a Good Thing?

Hannah D. Stacey and Matthew S. Miller. 

Comparative Immunogenicity of the 2014–2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children.

Jann Catherine Ang, Biao Wang, Joanne J.F. Wang, Peter Yu Fan Zeng, Florian Krammer, Brian J. Ward, Margaret L. Russell, Mark Loeb, and Matthew S. Miller.  Vaccines. 2019 August 7. Accepted.

Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films.

Vincent Leung, Jonathan Mapletoft, Ali Zhang, Amanda Lee, Fatemeh Vahedi, Marianne Chew, Alexandra Szewczyk, Jann Ang, Braeden Cowbrough, Matthew Miller, Ali Ashkar, and Carlos Filipe. Scientific Reports. 2019 May 7. Accepted.

Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders.

Steve P. Toniolo, Sam Afkhami, Ahmad Mahmood, Cecile Fradin, Brian D. Lichty, Matthew S. Miller, Zhou Xing, Emily D. Cranston, and Michael R. Thompson. International Journal of Pharmaceutics. 2019 February 19;108:173-178. doi: 10.1016/j.ijpharm.2019.02.035. 

Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses.

Ali Zhang, Hannah D. Stacey, Caitlyn E Mullarkey, Matthew S. Miller. J Immunol. 2019 Jan 15;202(2):335-340. doi: 10.4049/jimmunol.1801149. 

2018

Reviewing the evidence for viruses as environmental risk factors for ALS: A new perspective.

Daniel B. Celeste and Matthew S. Miller . Cytokine. 2018 Apr 20;108:173-178. doi: 10.1016/j.cyto.2018.04.010. 

 

“Gnothi Seauton”: Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy

Hannah D. Stacey, Neda Barjesteh, Jonathan P. Mapletoft  and Matthew S. Miller . Vaccines 2018, 6(2), 23; doi:10.3390/vaccines6020023

Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic

Alain Gagnon, Enrique Acosta, Stacey Hallman, Robert Bourbeau, Lisa Y. Dillon, Nadine Ouellette, David J.D. Earn, D. Ann Herring, Kris Inwood, Joaquin Madrenas, Matthew S. Miller. mBio vol 9(1). e2091-17

2017

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. 

Wenqian He*, Chi-Jene Chen, Caitlin E Mullarkey, Jennifer R Hamilton, Christine Wong, Paul E Leon, Melissa B Uccellini, Veronika Chromikova, Carole Henry, Kevin W Hoffman, Jean K Lim, Patrick C Wilson, Matthew S Miller, Florian Krammer, Peter Palese and Gene S Tan. 2017. Nature Communications 8(1):846.

Regulation of kynurenine biosynthesis during influenza virus infection.

Lana Gaelings, Sandra Söderholm, Andrii Bugai, Yu Fu, Jatin Nandania, Bert Schepens, Martina B. Lorey, Janne Tynell, Liesbeth Vande Ginste, Ronan Le Goffic, Matthew S Miller, Marika Kuisma, Varpu Marjomäki, Jef De Brabander, Sampsa Matikainen, Tuula A. Nyman, Dennis H Bamford, Xavier Saelens, Ilkka Julkunen, Henrik Paavilainen, Veijo Hukkanen, Vidya Velagapudi, Dennis E Kainov. 2017. FEBS J. 286:222-236. 

 

2016

Broadly neutralizing hemagglutinin stalk-specific antibodies induce potent phagocytosis of immune complexes by neutrophils in an Fc-dependent manner.

Caitlin E Mullarkey, Mark Bailey, Diana Golubeva, Gene Tan, Raffael Nachbagauer, Wenqian He, Kyle Novakowski, Dawn Bowdish, Matthew S Miller, and Peter Palese. 2016. mBio,7(5), pii: e01624-16.​

Abnormal Regulation of the Antiviral Response in Neurological/Neurodegenerative Diseases.

Mannie Man Wai Lam, Jonathan P Mapletoft and Matthew S Miller. 2016. Cytokine, 88:251-258.​

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza A virus

Wenqian He, Gene S Tan, Caitlin E Mullarkey, Amanda J Lee, Mannie Man Wai Lam, Florian Krammer, Carole Henry, Patrick C Wilson, Ali A Ashkar, Peter Palese and Matthew S Miller. 2016. Proc Natl Acad Sci USA, 113(42):11931-11936. 

Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact 

Paul E Leon, Wenqian He, Caitlin E Mullarkey, Mark J Bailey, Matthew S Miller, Florian Krammer, Peter Palese and Gene S Tan. 2016. Proc Natl Acad Sci USA, 113(40).​

Autoimmune variant PTPN22 C1858T is associated with impaired responses to influenza virus vaccination

Juliet N. Crabtree, Wenqian He, Weihua Guan, Mark Flage,  Matthew S Miller,  Erik J. Peterson. 2016. J Infect Dis. 214(2): 248-57​

CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

Changying Jiang, Zhicheng Zhou, Yanping Quan, Shilei Zhang, Tingting Wang, Xueqiang Zhao, Clayton Morrison, Mark T. Heise, Wenqian He, Matthew S. Miller, Xin Lin. 2016.Cell Reports. 14(10): 2389-401.

2015

 

Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets.

Raffael Nachbagauer, Matthew S Miller, Rong Hai, Alex Ryder, John Rose, Peter Palese, Adolfo García-Sastre, Florian Krammer, and Randy Albrecht. 2015. Journal of Virology. 90:3268-73

Measuring the neutralization potency of influenza A virus hemagglutinin stalk/stem-binding antibodies in polyclonal preparations by microneutralization assay.

Wenqian He, Caitlin E Mullarkey and Matthew S. Miller. 2015. Methods  pii: S1046-2023(15)00191-7.

SETX suppresses the antiviral transcriptional response and controls viral biogenesis.

Matthew S. Miller, Alexander Rialdi, Jessica Sook Yuin Ho, Micah Tilove, Luis Martinez-Gil, Natasha P. Moshkina,  Zuleyma Peralta, Justine Noel, Camilla Melegari,  Ana Maestre, Panagiotis Mitsopoulos, Joaquín Madrenas, Sven Heinz, Chris Benner, John A. T. Young, Alicia R. Feagins, Christopher Basler,  Ana Fernandez-Sesma, Olivier J. Becherel, Martin F. Lavin, Harm van Bakel, and Ivan Marazzi. 2015.  Nat Immunol. 16:485-494.

Is Antigenic Sin always "original?": Re-examining the evidence regarding circulation of a human H1 influenza virus immediately prior to the 1918 Spanish Flu.

Alain Gagnon, Enrique Acosta and Matthew S. Miller. 2015.  PLoS Pathog. 11:e1004615

Broadly-Neutralizing Anti-Influenza Virus Antibodies: Enhancement of Neutralizing Potency in Polyclonal Mixtures and IgA Backbones.

Wenqian He, Caitlin Mullarkey, J Duty, Thomas Moran, Peter Palese and Matthew S. Miller. 2015. J Virol 89:3610-3618

 

 

2014

Induction of broadly cross reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.Ali H. Ellebedy, Florian Krammer, Gui-Mei Li, Matthew S. Miller, Christopher Chiu, Jens Wrammert, Cathy Y. Cheng, Carl W. Davis, Megan McCausland, Rivka Elbein, Srilatha Edupuganti, Paul Spearman, Sarah F. Andrews, Patrick C. Wilson, Adolfo Garcia-Sastre, Mark J. Mulligan,  Aneesh K. Mehta, Peter Palese and Rafi Ahmed. 2014. Proc Natl Acad Sci U S A. 111:13133-13138

Peering into the crystal ball: Predicting influenza pandemics and vaccine efficacy.

Matthew S. Miller and Peter Palese. 2014. Cell 157:294-299

Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.

Florian Krammer, Rong Hai, Mark Yondola, Gene Tan, Victor Levya-Grado, Alex Ryder, Matthew S. Miller, John Rose, Peter Palese, Adolfo Garcia-Sastre and Randy Albrecht. 2014. J Virol. 88:3432-3442

 

 

2013

Neutralizing antibodies against previously-encountered influenza virus strains increase over time: A longitudinal analysis.

Matthew S. Miller, Thomas J. Gardner, Florian Krammer, Lauren C. Aguado, Domenico Tortorella, Christopher F. Basler and Peter Palese. 2013. Sci Transl Med 5:198ra107

Age-specific mortality during the 1918 influenza pandemic: Unravelling the mystery of high young adult mortality.

Alain Gagnon, Matthew S. Miller, Stacey Hallman, Robert Bourbeau, D. Ann Herring, David J.D. Earn and Joaquin Madrenas. 2013. PLoS One 8:e69586.

 

Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus.

Judith Alamares-Sapuay, Luis Martinez-Gil, Silke Stertz, Matthew S. Miller, Megan Shaw and Peter Palese. 2013. J Virol. 87:6020-6026.

1976 and 2009 H1N1 influenza virus vaccines boost anti-hemagglutinin stalk antibodies in humans.

Matthew S. Miller, Tshidi Tsibane, Florian Krammer, Rong Hai, Saad Rahmat, Christopher F. Basler and Peter Palese. 2013. J Infect. Dis. 207:98-105.

2012

Characterization of the 55 residue protein encoded by the 9S E1A mRNA of species C adenovirus.

Matthew S. Miller, Peter Pelka, Gregory J. Fonseca, Michael J. Cohen, Jenna N. Kelly, Stephen D. Barr, Roger J. A. Grand, Andrew S. Turnell, Peter Whyte, Joe S. Mymryk. 2012. J Virol. 86:4222-4233

2011

An Unhealthy Relationship: Viral Manipulation of the Nuclear Receptor Superfamily.

Matthew S. Miller and Joe S. Mymryk. 2011. Future Microbiol. 6:999-1019.

 

Adenovirus E1A directly targets the DP-1/E2F complex. 

Peter Pelka, Matthew S. Miller, Matthew Checchini, Ahmed Fayed Yousef, Dawn M. Bowdish, Fred Dick, Peter Whyte and Joe S. Mymryk. 2011. J Virol. 85:8841-8851.

2010

RASCAL is a new human cytomegalovirus-encoded protein localizing to the nuclear lamina and in cytoplasmic vesicles at late times post-infection.

Matthew S. Miller, Leesa Pennell, Wendy E. Furlong, Marc Geadah and Laura Hertel. 2010. J Virol. 84:6483-6496.

2009

Onset of human cytomegalovirus replication in fibroblasts requires the presence of an intact vimentin cytoskeleton.

Matthew S. Miller and Laura Hertel. 2009. J Virol. 83:7015-1728.

Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis.

Lana Mandic, Matthew S. Miller, Corinne Coulter, Brian Munshaw and Laura Hertel. 2009. J Gen. Virol. 90:1172-1182.

Miller Laboratory

Address: McMaster University

1280 Main St. West, MDCL-4074

Hamilton, ON, Canada, L8S 4L8

Phone: 905-525-9140

Email:  millerlab4704@gmail.com

2014 Miller Laboratory