2021

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Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library.

Jiuxing Li, Zijie Zhang, Jimmy Gu, Hannah D Stacey, Jann C Ang, Alfredo Capretta, Carlos D M Filipe, Karen L Mossman, Cynthia Balion, Bruno J Salena, Deborah Yamamura, Leyla Soleymani, Matthew S Miller, John D Brennan, Yingfu Li. Nucleic Acids Res. 2021 Jul 21. doi: 10.1093/nar/gkab574. PMID: 34232998

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IgA potentiates NETosis in response to viral infection.

Hannah D Stacey, Diana Golubeva, Alyssa Posca, Jann C Ang, Kyle E Novakowski, Muhammad Atif Zahoor, Charu Kaushic, Ewa Cairns, Dawn M E Bowdish, Caitlin E Mullarkey, Matthew S Miller. Proc Natl Acad Sci U S A. 2021 Jul 6. doi: 10.1073/pnas.2101497118. PMID: 34183391

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Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract.

Joshua J C McGrath, Danya Thayaparan, Steven P Cass, Jonathan P Mapletoft, Peter Y F Zeng, Joshua F E Koenig, Matthew F Fantauzzi, Puja Bagri, Bruce Ly, Rachel Heo, L Patrick Schenck, Pamela Shen, Matthew S Miller, Martin R Stämpfli. Mucosal Immunol. 2021 Jun 9. doi: 10.1038/s41385-021-00411-9. Online ahead of print. PMID: 34108594

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Neutrophils and Influenza: A Thin Line between Helpful and Harmful.

Sneha T George, Jonathan Lai, Julia Ma, Hannah D Stacey, Matthew S Miller, Caitlin E Mullarkey. Vaccines (BaseI). 2021 Jun 4. doi: 10.3390/vaccines9060597. PMID: 34199803

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A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge.

Zachary R Sia, Xuedan He, Ali Zhang, Jann C Ang, Shuai Shao, Amal Seffouh, Wei-Chiao Huang, Michael R D'Agostino, Amir Teimouri Dereshgi, Sambhara Suryaprakash, Joaquin Ortega, Hanne Andersen, Matthew S Miller, Bruce A Davidson, Jonathan F Lovell. Proc Natl Acad Sci U S A. 2021 Jun 1. doi: 10.1073/pnas.2025759118. PMID: 34050027

 

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses.

Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, Rajesh Abraham Jacob, Daniel Richard, Hassaan Maan, Jennifer A Aguiar, Wael L Demian, Kaushal Baid, Michael R D'Agostino, Jann Catherine Ang, Tetyana Murdza, Benjamin J-M Tremblay, Sam Afkhami, Mehran Karimzadeh, Aaron T Irving, Lily Yip, Mario Ostrowski, Jeremy A Hirota, Robert Kozak, Terence D Capellini, Matthew S Miller, Bo Wang, Samira Mubareka, Allison J McGeer, Andrew G McArthur, Andrew C Doxey, Karen Mossman. iScience. 2021 May 21. doi: 10.1016/j.isci.2021.102477. Epub 2021 Apr 26. PMID: 33937724

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Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets.

Eden Kapcan, Benjamin Lake, Zi Yang, Ali Zhang, Matthew S Miller, Anthony F Rullo. Biochemistry. 2021 May 18. doi: 10.1021/acs.biochem.1c00127. Epub 2021 Apr 30. PMID: 33930269

 

Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects.

Angela Huynh, Donald M Arnold, James W Smith, Jane C Moore, Ali Zhang, Zain Chagla, Bart J Harvey, Hannah D Stacey, Jann C Ang, Rumi Clare, Nikola Ivetic, Vasudhevan T Chetty, Dawn M E Bowdish, Matthew S Miller, John G Kelton, Ishac Nazy. Viruses. 2021 Apr 16. doi: 10.3390/v13040697. PMID: 33923828

 

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2020

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Probe Design for Simultaneous, Targeted Capture of Diverse Metagenomic Targets.

Zachery W Dickson, Dirk Hackenberger, Melanie Kuch, Art Marzok, Arinjay Banerjee, Karen Mossman, Matthew S Miller, Geoffrey B Golding, Hendrik Poinar. Cell Rep Methods. 2020 Dec 23. doi: 10.2139/ssrn.3754546

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Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike. 

Jérémie Prévost , Romain Gasser , Guillaume Beaudoin-Bussières , Jonathan Richard , Ralf Duerr , Annemarie Laumaea , Sai Priya Anand , Guillaume Goyette , Mehdi Benlarbi , Shilei Ding , Halima Medjahed , Antoine Lewin , Josée Perreault , Tony Tremblay , Gabrielle Gendron-Lepage , Nicolas Gauthier , Marc Carrier , Diane Marcoux , Alain Piché , Myriam Lavoie , Alexandre Benoit , Vilayvong Loungnarath , Gino Brochu , Elie Haddad, Hannah D Stacey , Matthew S Miller , Marc Desforges , Pierre J Talbot , Graham T Gould Maule , Marceline Côté , Christian Therrien , Bouchra Serhir , Renée Bazin , Michel Roger , Andrés Finzi.  Cell Rep Med. 2020 Oct 20. 1(7): 100126. DOI: 10.1016/j.xcrm.2020.100126

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Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus.

Arinjay Banerjee, Andrew C Doxey, Benjamin J-M Tremblay, Michael J Mansfield, Sonu Subudhi, Jeremy A Hirota, Matthew S Miller, Andrew G McArthur, Samira Mubareka, Karen Mossman. J Gen Virol. 2020 Sep 9. PMID: 32902372. DOI: 10.1099/jgv.0.001491

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Immunological considerations for COVID-19 vaccine strategies. 

Mangalakumari Jeyanathan, Sam Afkhami, Fiona Smaill, Matthew S Miller, Brian D Lichty, Zhou Xing. Nat. Rev. Immunol. 2020 Sep 4. 1-18. doi: 10.1038/s41577-020-00434-6.

 

Engineered Nanoparticle Applications for Recombinant Influenza Vaccines.  

Zachary R Sia, Matthew S Miller, Jonathan F Lovell. Mol Pharm. 2020 Aug 17. doi: 10.1021/acs.molpharmaceut.0c00383. Online ahead of print.PMID: 32787280

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Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.  

Jennifer A Aguiar, Benjamin J-M Tremblay, Michael J Mansfield, Owen Woody, Briallen Lobb, Arinjay Banerjee, Abiram Chandiramohan, Nicholas Tiessen, Quynh Cao, Anna Dvorkin-Gheva, Spencer Revill , Matthew S Miller, Christopher Carlsten, Louise Organ, Chitra Joseph, Alison John, Paul Hanson , Richard Austin, Bruce M McManus, Gisli Jenkins, Karen Mossman, Kjetil Ask, Andrew C Doxey, Jeremy A Hirota.  Eur Respir J. 2020 Jul 16:2001123. doi: 10.1183/13993003.01123-2020. Online ahead of print.PMID: 3267520  

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Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2.  

Arinjay Banerjee, Jalees A Nasir, Patrick Budylowski, Lily Yip, Patryk Aftanas, Natasha Christie, Ayoob Ghalami, Kaushal Baid, Amogelang R Raphenya, Jeremy A Hirota, Matthew S Miller, Allison J McGeer, Mario Ostrowski, Robert A Kozak, Andrew G McArthur, Karen Mossman, Samira Mubareka.  Emerg Infect Dis. 2020 Jun 19;26(9). doi: 10.3201/eid2609.201495. Online ahead of print.PMID: 32558639 

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Bat Influenza Viruses: Making a Double Agent of MHC Class II. 

Arinjay Banerjee, Karen L. Mossman, Matthew S. Miller.  Trends Microbiol. 2020 Sep;28(9):703-706. doi: 10.1016/j.tim.2020.04.006. Epub 2020 Apr 20.PMID: 3240914

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Age-specific incidence of influenza A responds to change in virus subtype dominance.

Alain Gagnon, Erinque Acosta, Matthew S. Miller. Demography. 2019 Oct 28. doi: 10.1007/s13524-019-00824-z. Online ahead of print.PMID: 31659681

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Repeated Seasonal Influenza Vaccination-How Much is Too Much of a Good Thing?

Hannah D. Stacey and Matthew S. Miller. J Infect Dis. 2020 Jun 29;222(2):173-175. doi: 10.1093/infdis/jiz434.

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2019

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Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016.

Acosta, E., Hallman S., Dillon LY, Ouellette N, Bourbeau R, Herring DA, Inwood Kb, Earn DJ, Madrenas J, Miller MS, Gagnon A. Demography. 2019 Oct;56(5):1723-1746.

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Comparative Immunogenicity of the 2014–2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children.

Jann Catherine Ang, Biao Wang, Joanne J.F. Wang, Peter Yu Fan Zeng, Florian Krammer, Brian J. Ward, Margaret L. Russell, Mark Loeb, and Matthew S. Miller.  Vaccines. 2019 August 7. Accepted.

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Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films.

Vincent Leung, Jonathan Mapletoft, Ali Zhang, Amanda Lee, Fatemeh Vahedi, Marianne Chew, Alexandra Szewczyk, Jann Ang, Braeden Cowbrough, Matthew Miller, Ali Ashkar, and Carlos Filipe. Scientific Reports. 2019 May 7. Accepted.

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Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders.

Steve P. Toniolo, Sam Afkhami, Ahmad Mahmood, Cecile Fradin, Brian D. Lichty, Matthew S. Miller, Zhou Xing, Emily D. Cranston, and Michael R. Thompson. International Journal of Pharmaceutics. 2019 February 19;108:173-178. doi: 10.1016/j.ijpharm.2019.02.035. 

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Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses.

Ali Zhang, Hannah D. Stacey, Caitlyn E Mullarkey, Matthew S. Miller. J Immunol. 2019 Jan 15;202(2):335-340. doi: 10.4049/jimmunol.1801149. 

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2018

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Reviewing the evidence for viruses as environmental risk factors for ALS: A new perspective.

Daniel B. Celeste and Matthew S. Miller . Cytokine. 2018 Apr 20;108:173-178. doi: 10.1016/j.cyto.2018.04.010. 

 

“Gnothi Seauton”: Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy

Hannah D. Stacey, Neda Barjesteh, Jonathan P. Mapletoft  and Matthew S. Miller . Vaccines 2018, 6(2), 23; doi:10.3390/vaccines6020023

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Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic

Alain Gagnon, Enrique Acosta, Stacey Hallman, Robert Bourbeau, Lisa Y. Dillon, Nadine Ouellette, David J.D. Earn, D. Ann Herring, Kris Inwood, Joaquin Madrenas, Matthew S. Miller. mBio vol 9(1). e2091-17

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2017

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Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. 

Wenqian He*, Chi-Jene Chen, Caitlin E Mullarkey, Jennifer R Hamilton, Christine Wong, Paul E Leon, Melissa B Uccellini, Veronika Chromikova, Carole Henry, Kevin W Hoffman, Jean K Lim, Patrick C Wilson, Matthew S Miller, Florian Krammer, Peter Palese and Gene S Tan. 2017. Nature Communications 8(1):846.

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Regulation of kynurenine biosynthesis during influenza virus infection.

Lana Gaelings, Sandra Söderholm, Andrii Bugai, Yu Fu, Jatin Nandania, Bert Schepens, Martina B. Lorey, Janne Tynell, Liesbeth Vande Ginste, Ronan Le Goffic, Matthew S Miller, Marika Kuisma, Varpu Marjomäki, Jef De Brabander, Sampsa Matikainen, Tuula A. Nyman, Dennis H Bamford, Xavier Saelens, Ilkka Julkunen, Henrik Paavilainen, Veijo Hukkanen, Vidya Velagapudi, Dennis E Kainov. 2017. FEBS J. 286:222-236. 

 

2016

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Broadly neutralizing hemagglutinin stalk-specific antibodies induce potent phagocytosis of immune complexes by neutrophils in an Fc-dependent manner.

Caitlin E Mullarkey, Mark Bailey, Diana Golubeva, Gene Tan, Raffael Nachbagauer, Wenqian He, Kyle Novakowski, Dawn Bowdish, Matthew S Miller, and Peter Palese. 2016. mBio,7(5), pii: e01624-16.​

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Abnormal Regulation of the Antiviral Response in Neurological/Neurodegenerative Diseases.

Mannie Man Wai Lam, Jonathan P Mapletoft and Matthew S Miller. 2016. Cytokine, 88:251-258.​

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Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza A virus

Wenqian He, Gene S Tan, Caitlin E Mullarkey, Amanda J Lee, Mannie Man Wai Lam, Florian Krammer, Carole Henry, Patrick C Wilson, Ali A Ashkar, Peter Palese and Matthew S Miller. 2016. Proc Natl Acad Sci USA, 113(42):11931-11936. ​

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Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact 

Paul E Leon, Wenqian He, Caitlin E Mullarkey, Mark J Bailey, Matthew S Miller, Florian Krammer, Peter Palese and Gene S Tan. 2016. Proc Natl Acad Sci USA, 113(40).​

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Autoimmune variant PTPN22 C1858T is associated with impaired responses to influenza virus vaccination

Juliet N. Crabtree, Wenqian He, Weihua Guan, Mark Flage,  Matthew S Miller,  Erik J. Peterson. 2016. J Infect Dis. 214(2): 248-57​

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CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

Changying Jiang, Zhicheng Zhou, Yanping Quan, Shilei Zhang, Tingting Wang, Xueqiang Zhao, Clayton Morrison, Mark T. Heise, Wenqian He, Matthew S. Miller, Xin Lin. 2016.Cell Reports. 14(10): 2389-401.

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2015

 

Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets.

Raffael Nachbagauer, Matthew S Miller, Rong Hai, Alex Ryder, John Rose, Peter Palese, Adolfo García-Sastre, Florian Krammer, and Randy Albrecht. 2015. Journal of Virology. 90:3268-73

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Measuring the neutralization potency of influenza A virus hemagglutinin stalk/stem-binding antibodies in polyclonal preparations by microneutralization assay.

Wenqian He, Caitlin E Mullarkey and Matthew S. Miller. 2015. Methods  pii: S1046-2023(15)00191-7.

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SETX suppresses the antiviral transcriptional response and controls viral biogenesis.

Matthew S. Miller, Alexander Rialdi, Jessica Sook Yuin Ho, Micah Tilove, Luis Martinez-Gil, Natasha P. Moshkina,  Zuleyma Peralta, Justine Noel, Camilla Melegari,  Ana Maestre, Panagiotis Mitsopoulos, Joaquín Madrenas, Sven Heinz, Chris Benner, John A. T. Young, Alicia R. Feagins, Christopher Basler,  Ana Fernandez-Sesma, Olivier J. Becherel, Martin F. Lavin, Harm van Bakel, and Ivan Marazzi. 2015.  Nat Immunol. 16:485-494.

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Is Antigenic Sin always "original?": Re-examining the evidence regarding circulation of a human H1 influenza virus immediately prior to the 1918 Spanish Flu.

Alain Gagnon, Enrique Acosta and Matthew S. Miller. 2015.  PLoS Pathog. 11:e1004615

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Broadly-Neutralizing Anti-Influenza Virus Antibodies: Enhancement of Neutralizing Potency in Polyclonal Mixtures and IgA Backbones.

Wenqian He, Caitlin Mullarkey, J Duty, Thomas Moran, Peter Palese and Matthew S. Miller. 2015. J Virol 89:3610-3618

 

 

2014

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Induction of broadly cross reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.Ali H. Ellebedy, Florian Krammer, Gui-Mei Li, Matthew S. Miller, Christopher Chiu, Jens Wrammert, Cathy Y. Cheng, Carl W. Davis, Megan McCausland, Rivka Elbein, Srilatha Edupuganti, Paul Spearman, Sarah F. Andrews, Patrick C. Wilson, Adolfo Garcia-Sastre, Mark J. Mulligan,  Aneesh K. Mehta, Peter Palese and Rafi Ahmed. 2014. Proc Natl Acad Sci U S A. 111:13133-13138

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Peering into the crystal ball: Predicting influenza pandemics and vaccine efficacy.

Matthew S. Miller and Peter Palese. 2014. Cell 157:294-299

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Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.

Florian Krammer, Rong Hai, Mark Yondola, Gene Tan, Victor Levya-Grado, Alex Ryder, Matthew S. Miller, John Rose, Peter Palese, Adolfo Garcia-Sastre and Randy Albrecht. 2014. J Virol. 88:3432-3442

 

 

2013

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Neutralizing antibodies against previously-encountered influenza virus strains increase over time: A longitudinal analysis.

Matthew S. Miller, Thomas J. Gardner, Florian Krammer, Lauren C. Aguado, Domenico Tortorella, Christopher F. Basler and Peter Palese. 2013. Sci Transl Med 5:198ra107

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Age-specific mortality during the 1918 influenza pandemic: Unravelling the mystery of high young adult mortality.

Alain Gagnon, Matthew S. Miller, Stacey Hallman, Robert Bourbeau, D. Ann Herring, David J.D. Earn and Joaquin Madrenas. 2013. PLoS One 8:e69586.

 

Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus.

Judith Alamares-Sapuay, Luis Martinez-Gil, Silke Stertz, Matthew S. Miller, Megan Shaw and Peter Palese. 2013. J Virol. 87:6020-6026.

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1976 and 2009 H1N1 influenza virus vaccines boost anti-hemagglutinin stalk antibodies in humans.

Matthew S. Miller, Tshidi Tsibane, Florian Krammer, Rong Hai, Saad Rahmat, Christopher F. Basler and Peter Palese. 2013. J Infect. Dis. 207:98-105.

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2012

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Characterization of the 55 residue protein encoded by the 9S E1A mRNA of species C adenovirus.

Matthew S. Miller, Peter Pelka, Gregory J. Fonseca, Michael J. Cohen, Jenna N. Kelly, Stephen D. Barr, Roger J. A. Grand, Andrew S. Turnell, Peter Whyte, Joe S. Mymryk. 2012. J Virol. 86:4222-4233

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2011

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An Unhealthy Relationship: Viral Manipulation of the Nuclear Receptor Superfamily.

Matthew S. Miller and Joe S. Mymryk. 2011. Future Microbiol. 6:999-1019.

 

Adenovirus E1A directly targets the DP-1/E2F complex. 

Peter Pelka, Matthew S. Miller, Matthew Checchini, Ahmed Fayed Yousef, Dawn M. Bowdish, Fred Dick, Peter Whyte and Joe S. Mymryk. 2011. J Virol. 85:8841-8851.

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2010

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RASCAL is a new human cytomegalovirus-encoded protein localizing to the nuclear lamina and in cytoplasmic vesicles at late times post-infection.

Matthew S. Miller, Leesa Pennell, Wendy E. Furlong, Marc Geadah and Laura Hertel. 2010. J Virol. 84:6483-6496.

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2009

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Onset of human cytomegalovirus replication in fibroblasts requires the presence of an intact vimentin cytoskeleton.

Matthew S. Miller and Laura Hertel. 2009. J Virol. 83:7015-1728.

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Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis.

Lana Mandic, Matthew S. Miller, Corinne Coulter, Brian Munshaw and Laura Hertel. 2009. J Gen. Virol. 90:1172-1182.